Preprints
Hartman E, Samsudin F, Bond PJ, Schmidtchen A, Malmström J. Mining the endogenous peptidome for peptide binders with deep learning-driven optimization and molecular simulations bioRxiv 2025.01.20.633551; doi: https://doi.org/10.1101/2025.01.20.633551
Malmström E., Hauri S., Åhrman E, Mohanty T, Linder A, Nozohoor S, Tingstedt B, Regner S, Elfving P, Bjermer L, Forsvall A, Doyle A, Magnusson M, Hedenfalk I, Brandt C, Nilsson E, Dahlin L, Malm J, Malmström L,* Nimeus E*, Malmström J*. Interfering the composition of the blood plasma proteome by a human consensus proteome atlas. bioRxiv 2024.05.07.592979.
Scott. A.*, Mellhammar L.*, Malmström E.*, Gustaffson A., Bakoci A., Isaksson M., Mohanty T., Thelaus L., Kahn F., Malmström L., Malmström J*., Linder A*., Population scale proteomics enables adaptive digital twin modelling in sepsis
medRxiv 2024.03.20.24304575
Chowdhury S., Gomez Toledo A., Hjortswang E., Sorrentino JT, Lewis NE, Bläckberg A., Ekström S., Izadi A., Nordenfelt P., Malmström L., Rasmussen M., Malmström J. Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow. bioRxiv, 2023.11. 07.565977
Selected publications
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjørn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells. Nat Metab. 2025 Jan;7(1):212-227. doi: 10.1038/s42255-024-01193-7.
Tang D, Khakzad H, Hjortswang E, Malmström L, Ekström S, Happonen L, Malmström J. Streptolysin O accelerates the conversion of plasminogen to plasmin. Nat Commun. 2024 Nov 25;15(1):10212. doi: 10.1038/s41467-024-54173-6.
Hartman E, Forsberg F, Kjellström S, Petrlova J, Luo C, Scott A, Puthia M, Malmström J, Schmidtchen A. Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data. Nat Commun. 2024 Aug 20;15(1):7128. doi: 10.1038/s41467-024-51589-y.
Tang D, Gueto-Tettay C, Hjortswang E, Ströbaek J, Ekström S, Happonen L, Malmström L, Malmström J. Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O. Anal Chem. 2024 Jun 4;96(22):9060-9068. doi: 10.1021/acs.analchem.4c00596.
Izadi A, Karami Y, Bratanis E, Wrighton S, Khakzad H, Nyblom M, Olofsson B, Happonen L, Tang D, Sundwall M, Godzwon M, Chao Y, Toledo AG, Schmidt T, Ohlin M, Nilges M, Malmström J, Bahnan W, Shannon O, Malmström L, Nordenfelt P. The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies. Nat Commun. 2024 Apr 27;15(1):3600. doi: 10.1038/s41467-024-47928-8.
Toledo AG, Bratanis E, Velásquez E, Chowdhury S, Olofsson B, Sorrentino JT, Karlsson C, Lewis NE, Esko JD, Collin M, Shannon O, Malmström J. Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections. Nat Commun. 2023 Oct 23;14(1):6693.
Hartman E, Scott AM, Karlsson C, Mohanty T, Vaara ST, Linder A, Malmström L, Malmström J. Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis. Nat Commun. 2023 Sep 2;14(1):5359.
Mohanty T, Karlsson CAQ, Chao Y, Malmström E, Bratanis E, Grentzmann A, Mørch M, Nizet V, Malmström L, Linder A, Shannon O, Malmström J. A pharmacoproteomic landscape of organotypic intervention responses in Gram-negative sepsis. Nat Commun. 2023 Jun 17;14(1):3603.
Tanner L, Single AB, Bhongir RKV, Heusel M, Mohanty T, Karlsson CAQ, Pan L, Clausson CM, Bergwik J, Wang K, Andersson CK, Oommen RM, Erjefält JS, Malmström J, Wallner O, Boldogh I, Helleday T, Kalderén C, Egesten A. Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nat Commun. 2023 Feb 6;14(1):643.
Bahnan W, Happonen L, Khakzad H, Kumra Ahnlide V, de Neergaard T, Wrighton S, André O, Bratanis E, Tang D, Hellmark T, Björck L, Shannon O, Malmström L, Malmström J, Nordenfelt P. A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function. EMBO Mol Med. 2023 Feb 8;15(2):e16208.
Governa V, Talbot H, Gonçalves de Oliveira K, Cerezo-Magaña M, Bång-Rudenstam A, Johansson MC, Månsson AS, Forsberg-Nilsson K, Marko-Varga G, Enríquez Pérez J, Darabi A, Malmström J, Bengzon J, Welinder C, Belting M. Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2114456119.
Happonen L, Hauri S, Svensson Birkedal G, Karlsson C, de Neergaard T, Khakzad H, Nordenfelt P, Wikström M, Wisniewska M, Björck L, Malmström L, Malmström J. A quantitative Streptococcus pyogenes-human protein-protein interaction map reveals localization of opsonizing antibodies. Nat Commun. 2019 Jun 21;10(1):2727
Hauri S, Khakzad H, Happonen L, Teleman J, Malmström J*, Malmström L*. Rapid determination of quaternary protein structures in complex biological samples. Nat Commun. 2019 Jan 14;10(1):192.
Mohanty T, Fisher J, Bakochi A, Neumann A, Cardoso JFP, Karlsson CAQ, Pavan C, Lundgaard I, Nilson B, Reinstrup P, Bonnevier J, Cederberg D, Malmström J, Bentzer P, Linder A. Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis. Nat Commun. 2019 Apr 10;10(1):1667.
Naegeli A, Bratanis E, Karlsson C, Shannon O, Kalluru R, Linder A, Malmström J, Collin M. Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis. J Exp Med. 2019 Jul 1;216(7):1615-1629.
Malmström E, Kilsgård O, Hauri S, Smeds E, Herwald H, Malmström L, Malmström J. Large-scale inference of protein tissue origin in gram-positive sepsis plasma using quantitative targeted proteomics. Nat Commun. 2016 Jan 6;7:10261.
Röst HL, Rosenberger G, Navarro P, Gillet L, Miladinović SM, Schubert OT, Wolski W, Collins BC, Malmström J, Malmström L, Aebersold R. OpenSWATH enables automated, targeted analysis of data-independent acquisition MS data. Nat Biotechnol. 2014 Mar;32(3):219-23.
Karlsson C*, Malmström L*, Aebersold R, Malmström J. Proteome-wide selected reaction monitoring assays for the human pathogen Streptococcus pyogenes. Nat Commun. 2012 Dec 18;3:1301. doi: 10.1038/ncomms2297.
Nordenfelt P, Waldemarson S, Linder A, Mörgelin M, Karlsson C, Malmström J, Björck L. Antibody orientation at bacterial surfaces is related to invasive infection. J Exp Med. 2012 Dec 10. PubMed PMID: 23230002.
Malmström, J., Beck, M., Schmidt, A., Lange, V., Deutsch, E.W., and Aebersold, R. Proteome-wide cellular protein concentrations of the human pathogen Leptospira interrogans. Nature 2009 460, 762-765.
Beck, M., Malmström, J, Lange, V., Schmidt, A., Deutsch, E.W., and Aebersold, R. Visual proteomics of the human pathogen Leptospira interrogans. Nat Methods 2009 6, 817-823.
Schelhaas, M., Malmström, J., Pelkmans, L., Haugstetter, J., Ellgaard, L., Grunewald, K., and Helenius, A. Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell 2007 131, 516-529.
Brunner, E., Ahrens, C.H., Mohanty, S., Baetschmann, H., Loevenich, S., Potthast, F., Deutsch, E.W., Panse, C., de Lichtenberg, U., Rinner, O. Malmström, J., et al. A high-quality catalog of the Drosophila melanogaster proteome. Nat Biotechnol 2007 25, 576-583.